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Medical Affairs Manager Salary in the United States

How much does a Medical Affairs Manager make in the United States?

As of August 01, 2026, the average salary for a Medical Affairs Manager in the United States is $134,297 per year, which breaks down to an hourly rate of $65.

However, a Medical Affairs Manager's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $158,791
  • Majority Range (25th-75th percentile): $124,246 to $147,118
  • Entry-Level (10th percentile): $115,095
Salary Factors Salary-Boosting Skills Salary by Experience Related Job Salaries Top Paying Cities Explore Related Jobs

Key Factors That Influence Medical Affairs Manager Salaries

A Medical Affairs Manager's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.

How Experience Level Affects Medical Affairs Manager Salaries?

Experience is a primary driver of a Medical Affairs Manager's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Entry-Level (less than 1 year): $130,547
  • Early Career (1-2 years): $130,997
  • Mid-Level (2-4 years): $132,497
  • Senior-Level (5-8 years): $134,297
  • Expert (over 8 years): $137,550
Levels Salary
Entry Level Medical Affairs Manager$130,547
Intermediate Level Medical Affairs Manager$130,997
Senior Level Medical Affairs Manager$132,497
Specialist Level Medical Affairs Manager$134,297
Expert Level Medical Affairs Manager$137,550
View as Graph

How Do Medical Affairs Managers Salaries Vary from State to State?

Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Medical Affairs Managers. For example, consider the average annual salaries in these key locations:
  • District of Columbia: $148,694.
  • California: $148,130.
  • Massachusetts: $146,155.

Top Paying Cities for Medical Affairs Manager

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $169,389
  • San Francisco: $167,534
  • Oakland: $164,003

Medical Affairs Manager Salary by Company Size: Startups vs. Enterprise

Medical Affairs Manager salary potential scales significantly with company size. Data shows that Enterprise companies (5,000+ employees) pay the highest average salary at around $150,716. While startup companies pay approximate $127,818.

Medical Affairs Manager Salary by Company Size

Company Size Employees Average Salary
Startup 1~50 $127,818
Growth Stage 51~500 $135,101
Established 501~5000 $145,611
Enterprise 5000+ $150,716

Medical Affairs Manager Salary by Industry: Top Paying Sectors

For Medical Affairs Manager roles, the industry you choose can affect earning potential by as much as 90% (the gap between the highest and lowest paying industries). Data shows that the Insurance and Edu., Gov't. & Nonprofit sectors offer the strongest compensation, at 50% above the average. In contrast, Medical Affairs Manager positions in Pharmaceuticals or Biotechnology typically offer lower base pay, as these industries often view Medical Affairs Manager as a support function rather than a direct revenue driver.

The top paying industries for a Medical Affairs Manager

Industry Sector Average Annual Salary Average Hourly Rate Pay vs.Avg
Insurance$201,446$97.050%
Edu., Gov't. & Nonprofit$161,156$77.020%

Medical Affairs Manager Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Medical Affairs Manager's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

Last Updated on August 01, 2026
$124,246
Average $134,297/year
$147,118
$10,354
Average $11,191/month
$12,260
$2,389
Average $2,583/week
$2,829
$60
Average $65/hour
$71
Annual Salary Monthly Pay Weekly Pay Hourly Wage
75th Percentile $147,118 $12,260 $2,829 $71
Average $134,297 $11,191 $2,583 $65
25th Percentile $124,246 $10,354 $2,389 $60

Medical Affairs Manager Salary Growth & Career Path

Medical Affairs Manager

Next Role

Advancement

For a Medical Affairs Manager, the most direct path to higher earnings is advancing to the Medical Affairs Senior Manager role. This promotion typically comes with a significant pay increase, bringing the average annual salary to $169,615 - a projected growth of 26% over your current level.

Most common benefits for Medical Affairs Manager

  • Social Security
  • 401 (k)
  • Disability
  • Healthcare
  • Pension
  • Time Off (days)

Common company salaries for Medical Affairs Manager

Here are companies hiring for Medical Affairs Manager and their salaries, click below for more details.

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FAQ about Medical Affairs Manager

1. Where can a Medical Affairs Manager earn the most?

A Medical Affairs Manager's earning potential can vary widely depending on several factors, including location, industry, experience, education, and the specific employer. According to the latest salary data by Salary.com, a Medical Affairs Manager earns the most in San Jose, CA, where the annual salary of a Medical Affairs Manager is $169,389.

2. What is the highest pay for Medical Affairs Manager?

The highest pay for Medical Affairs Manager is $158,791.

3. What is the lowest pay for Medical Affairs Manager?

The lowest pay for Medical Affairs Manager is $115,095.

4. What are the responsibilities of Medical Affairs Manager?

Manages clinical trials and associated research activities for medical product development. Leads study design and execution and the collection and reporting of study data. Advises on and ensures adherence to clinical protocols. Recruits and negotiates fees with clinical investigators. Coordinates regulatory report submissions, monitors compliance, and concludes studies. May require an advanced degree. Typically reports to a director. Manages subordinate staff in the day-to-day performance of their jobs. True first level manager. Ensures that project/department milestones/goals are met and adhering to approved budgets. Has full authority for personnel actions. Typically requires 5 years experience in the related area as an individual contributor. 1-3 years supervisory experience may be required. Extensive knowledge of the function and department processes.

5. What industry pays the highest salary for Medical Affairs Manager?

The Insurance industry offers the highest average compensation for Medical Affairs Manager roles, with salaries approximately 50% above the market median.

Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

With the most extensive online, real-time compensation data available, Salary.com helps you pinpoint your exact pay target.

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