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Clinical Research Project Management Manager, Sr. Salary in the United States

How much does a Clinical Research Project Management Manager, Sr. make in the United States?

As of August 01, 2026, the average salary for a Clinical Research Project Management Manager, Sr. in the United States is $146,923 per year, which breaks down to an hourly rate of $71.

However, a Clinical Research Project Management Manager, Sr.'s salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $175,414
  • Majority Range (25th-75th percentile): $135,235 to $161,836
  • Entry-Level (10th percentile): $124,594
Salary Factors Salary-Boosting Skills Salary by Experience Related Job Salaries Top Paying Cities Explore Related Jobs

Key Factors That Influence Clinical Research Project Management Manager, Sr. Salaries

A Clinical Research Project Management Manager, Sr.'s salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.

How Experience Level Affects Clinical Research Project Management Manager, Sr. Salaries?

Experience is a primary driver of a Clinical Research Project Management Manager, Sr.'s salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Clinical Research Project Management Supervisor (10+ years): $97,243
  • Clinical Research Project Management Manager (10+ years): $121,643
  • Clinical Research Project Management Manager, Sr. (10+ years): $146,923
  • Clinical Research Project Management Director (10+ years): $167,931
  • VP of Clinical Research Project Management (10+ years): $218,111
Job Role Years of Experience Average Salary
Clinical Research Project Management Supervisor10+ years$97,243
Clinical Research Project Management Manager10+ years$121,643
Clinical Research Project Management Manager, Sr.10+ years$146,923
Clinical Research Project Management Director10+ years$167,931
VP of Clinical Research Project Management10+ years$218,111
View as Graph

How Do Clinical Research Project Management Manager, Sr.s Salaries Vary from State to State?

Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Clinical Research Project Management Manager, Sr.s. For example, consider the average annual salaries in these key locations:
  • District of Columbia: $162,673.
  • California: $162,056.
  • Massachusetts: $159,896.

Top Paying Cities for Clinical Research Project Management Manager, Sr.

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $185,314
  • San Francisco: $183,285
  • Oakland: $179,422

Clinical Research Project Management Manager, Sr. Salary by Company Size: Startups vs. Enterprise

Clinical Research Project Management Manager, Sr. salary potential scales significantly with company size. Data shows that Enterprise companies (5,000+ employees) pay the highest average salary at around $166,727. While startup companies pay approximate $141,479.

Clinical Research Project Management Manager, Sr. Salary by Company Size

Company Size Employees Average Salary
Startup 1~50 $141,479
Growth Stage 51~500 $149,507
Established 501~5000 $161,113
Enterprise 5000+ $166,727

Clinical Research Project Management Manager, Sr. Salary by Industry: Top Paying Sectors

For Clinical Research Project Management Manager, Sr. roles, the industry you choose can affect earning potential by as much as 60% (the gap between the highest and lowest paying industries). Data shows that the Healthcare and Chemicals sectors offer the strongest compensation, at 40% above the average. In contrast, Clinical Research Project Management Manager, Sr. positions in Pharmaceuticals or Biotechnology typically offer lower base pay, as these industries often view Clinical Research Project Management Manager, Sr. as a support function rather than a direct revenue driver.

The top paying industries for a Clinical Research Project Management Manager, Sr.

Industry Sector Average Annual Salary Average Hourly Rate Pay vs.Avg
Healthcare$205,692$99.040%
Chemicals$161,615$78.010%

Clinical Research Project Management Manager, Sr. Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Clinical Research Project Management Manager, Sr.'s annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

Last Updated on August 01, 2026
$135,235
Average $146,923/year
$161,836
$11,270
Average $12,244/month
$13,486
$2,601
Average $2,825/week
$3,112
$65
Average $71/hour
$78
Annual Salary Monthly Pay Weekly Pay Hourly Wage
75th Percentile $161,836 $13,486 $3,112 $78
Average $146,923 $12,244 $2,825 $71
25th Percentile $135,235 $11,270 $2,601 $65

Clinical Research Project Management Manager, Sr. Salary Growth & Career Path

Clinical Research Project Management Manager, Sr.

Next Role

Advancement

For a Clinical Research Project Management Manager, Sr., the most direct path to higher earnings is advancing to the Clinical Research Project Management Director role. This promotion typically comes with a significant pay increase, bringing the average annual salary to $167,931 - a projected growth of 14% over your current level.

Most common benefits for Clinical Research Project Management Manager, Sr.

  • Social Security
  • 401 (k)
  • Disability
  • Healthcare
  • Pension
  • Time Off (days)

Common company salaries for Clinical Research Project Management Manager, Sr.

Here are companies hiring for Clinical Research Project Management Manager, Sr. and their salaries, click below for more details.

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FAQ about Clinical Research Project Management Manager, Sr.

1. Where can a Clinical Research Project Management Manager, Sr. earn the most?

A Clinical Research Project Management Manager, Sr.'s earning potential can vary widely depending on several factors, including location, industry, experience, education, and the specific employer. According to the latest salary data by Salary.com, a Clinical Research Project Management Manager, Sr. earns the most in San Jose, CA, where the annual salary of a Clinical Research Project Management Manager, Sr. is $185,314.

2. What is the highest pay for Clinical Research Project Management Manager, Sr.?

The highest pay for Clinical Research Project Management Manager, Sr. is $175,414.

3. What is the lowest pay for Clinical Research Project Management Manager, Sr.?

The lowest pay for Clinical Research Project Management Manager, Sr. is $124,594.

4. What are the responsibilities of Clinical Research Project Management Manager, Sr.?

Leads and manages a team of clinical research project managers. Oversees and monitors project plans to ensure projects are timely, accurate, and produce precise results. Develops and implements clinical research guidelines, processes, and procedures. Establishes data collection and reporting processes to capture key metrics of project activities against performance indicators and key deliverables. Provides solutions to potential risks/issues and facilitates actions to keep projects on track. Ensures the project is planned and conducted in accordance with all applicable regulations, standard operating procedures, and good clinical practices (GCP). Requires a bachelor's degree. Typically reports to a director. Typically manages through subordinate managers and professionals in larger groups of moderate complexity. Provides input to strategic decisions that affect the functional area of responsibility. May give input into developing the budget. Typically requires 3+ years of managerial experience. Capable of resolving escalated issues arising from operations and requiring coordination with other departments.

5. What industry pays the highest salary for Clinical Research Project Management Manager, Sr.?

The Healthcare industry offers the highest average compensation for Clinical Research Project Management Manager, Sr. roles, with salaries approximately 40% above the market median.

Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

With the most extensive online, real-time compensation data available, Salary.com helps you pinpoint your exact pay target.

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