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As of August 01, 2026, the average salary for a Clinical Research Nurse in South Dakota is $84,109 per year, which breaks down to an hourly rate of $40.
However, a Clinical Research Nurse's salary can vary significantly. Here’s a look at the typical salary range:
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Clinical Research Nurse Salaries by Percentile
| Annual Salary |
Monthly Pay |
Weekly Pay |
Hourly Wage |
|
| 75th Percentile | $90,219 | $7,518 | $1,735 | $43 |
| Average | $84,109 | $7,009 | $1,617 | $40 |
| 25th Percentile | $74,970 | $6,248 | $1,442 | $36 |
University of Iowa - Sioux Falls, SD
Professional Case Management - Pierre, SD
Sanford Health - Sioux Falls, SD
Avera Health - Sioux Falls, SD
A Clinical Research Nurse's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.
Experience is a primary driver of a Clinical Research Nurse's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here’s how the average salary grows at different career stages:
| Levels | Salary |
|---|---|
| Clinical ... Level Clinical Research Nurse | $83,660 |
| Clinical ... Level Clinical Research Nurse | $54,137 |
| Clinical ... Level Clinical Research Nurse | $62,643 |
| Scientist... Level Clinical Research Nurse | $88,964 |
| Clinical ... Level Clinical Research Nurse | $96,105 |
What Am I Worth?
Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Clinical Research Nurses. For example, consider the average annual salaries in these key locations:
Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:
For Clinical Research Nurse roles, the industry you choose can affect earning potential by as much as 40% (the gap between the highest and lowest paying industries). Data shows that the Biotechnology and Healthcare sectors offer the strongest compensation, at 20% above the average. In contrast, Clinical Research Nurse positions in Edu., Gov't. & Nonprofit or Business Services typically offer lower base pay, as these industries often view Clinical Research Nurse as a support function rather than a direct revenue driver.
| Industry Sector | Average Annual Salary | Average Hourly Rate | Pay vs.Avg |
|---|---|---|---|
| Biotechnology | $100,931 | $49.0 | 20% |
| Healthcare | $92,520 | $44.0 | 10% |
Understanding how a Clinical Research Nurse's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.
| Annual Salary | Monthly Pay | Weekly Pay | Hourly Wage | |
|---|---|---|---|---|
| 75th Percentile | $90,219 | $7,518 | $1,735 | $43 |
| Average | $84,109 | $7,009 | $1,617 | $40 |
| 25th Percentile | $74,970 | $6,248 | $1,442 | $36 |
Ready to take the next step in your career? Browse thousands of current Clinical Research Nurse job openings on our job board. Use the search bar below to find your perfect match.
Ophthalmology Ltd
Sioux Falls, SD
Ophthalmology Ltd | Sioux Falls, SD
Job Description. Job Description. Over the years, Ophthalmology LTD's name has become associated with the highest quality of comprehensive medical and surg... more
2 Days Ago
Monument Health
Rapid City, SD
Monument Health | Rapid City, SD
Clinical Resource Nurse. The Clinical Resource Nurse must demonstrate the knowledge and skills necessary to function as a nursing resource to physicians, s... more
5 Days Ago
Avera Health
Chancellor, SD
Avera Health | Chancellor, SD
Location:Avera Cancer Institute-Sioux FallsWorker Type:RegularWork Shift:Day Shift (United States of America)Pay Range:The pay range for this position is l... more
6 Days Ago
ELEVATE CLINICAL RESEARCH, INC.
North Sioux City, SD
ELEVATE CLINICAL RESEARCH, INC. | North Sioux City, SD
Job Description. Job Description. About Company. Elevate Clinical Research is a mission‑driven organization expanding access to high‑quality clinical trial... more
2 Days Ago
University of Cincinnati
MT AUBURN, OH
University of Cincinnati | MT AUBURN, OH
The University of Cincinnati seeks a Clinical Research Professional to support studies in the Division of Rheumatology, Allergy & Immunology. This role coo... more
3 Days Ago
Professional Case Management
LOCKWOOD, MT
Professional Case Management | LOCKWOOD, MT
Professional Case Management seeks an RN Adolescent Clinical Research nurse to provide in-home care to adolescent participants with complex medical needs. ... more
7 Days Ago
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