As of April 01, 2026, the average annual salary for general surgery nurse practitioner in the US is $125,346, equivalent to $60 per hour, $2,411 weekly, or $10,446 monthly. These figures, sourced from Salary.com’s real-time job posting scans, highlight competitive earning potential for general surgery nurse practitioner in cities like Santa Clara, San Jose, and Fremont.
Annually Salaries for general surgery nurse practitioner in the US vary widely, spanning from $112,409 to $140,439. Most professionals fall between the 25th percentile ($118,574) and 75th percentile ($133,246), while top earners (90th percentile) make $140,439 per year. This $14,672 pay gap underscores opportunities for salary growth through certifications, specialized skills like Collaboration or Psychiatric, or targeting high-paying regions like District of Columbia or California.
Location and experience significantly influence earnings. For example, District of Columbia general surgery nurse practitioner often earn 10.7% above national averages due to demand from Fortune 65 companies and industry startups. Professionals are advised to focus on high-growth sectors like to offset market challenges.
